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334 Beyond degradation failure, autophagy-lysosomal dysfunction contributes to the pathological propagation of aggregation-prone proteins

The role of membrane proteolysis, particularly through pathways such as ERAD and intramembrane proteolysis, is crucial for cardiovascular health

Additionally, A deposition also led to lipid peroxidation and ROS generation

Iron overload downregulates GPX4 and SLC7A11 expression in chondrocytes and activates the p53/ACSL4 axis, driving lipid ROS accumulation and ferroptosis

Likewise, results obtained in various diet-induced MASLD/MASH rodent models revealed a marked reduction in CAT activity in the serum as well as the liver of these animals as compared to respective controls (Dai et al

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