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In some centers, a BH4-loading test is also performed measuring Phe levels at different times after a single dose of sapropterin dihydrochloride (commercial BH4 analogue) (see Section 4 below) [28]

However, unfavorable effects of ALDH2*2 allele have been reported in terms of the risk of some diseases such as osteoporosis [25] and neurodegenerative diseases [24, 26, 27]

Severe local depletion of arginine (arginine starvation) within this niche constitutes a fundamental mechanism of immune evasion ( Figure 3 )

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It acts as a precursor to Retinol that supports cell growth

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