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10.1016/j.redox.2015.06.020 188 VermaA

It is an alteration in the balance of prooxidant /antioxidant system in favour of prooxidant with attendant lethal effects with resultant damage to the cellular macromolecules (Fig

It is less irritating than salicylic acid due to its large molecule size

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30,31 This process allows the cancer cells to survive in relatively nutrient-poor environments, taking up a number of different macromolecules derived from both the periphery (probably accumulating in oedema) and necrotic areas of the tumour