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It is the oxidizing action of such acids that potentially result in skin irritation reactions once they reach the viable skin layers 3

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doi: 10.3389/fnut.2026.1676497 Received 30 July 2025 Revised 18 December 2025 Accepted 05 January 2026 Published 13 February 2026 Volume 13 - 2026 Edited by Senthil Kumaran Satyanarayanan, Hong Kong Institute of Innovation and Technology, Hong Kong SAR, China Reviewed by Luciene Bruno Vieira, Federal University of Minas Gerais, Brazil Iffet Ipek Bosgelmez, Erciyes University, Trkiye Updates Copyright 2026 Miteva, Laurenti, Mattioli, Di Risola, Mariano and Mosca

Research protocols typically start at 2550mg daily for tolerance assessment, then escalate to 50100mg based on individual response and objective metabolic markers