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Findings from animal research suggest episodes of heavy drinking can cause a decrease in blood and liver selenium levels, resulting in lower glutathione activity and greater oxidative stress (Ojeda 2015)

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[55] established a rat kidney stone model by injecting glyoxalate and found that the mitochondria in rat RTECs became smaller and increased in membrane density, and the mitochondria were severely damaged

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doi: 10.1038/s41467-019-13668-3 36 NunnariJSuomalainenA