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However, NPs exhibiting anionic surface charge are also used in AD treatment: in this case the starting polymers or the conjugated molecules are characterized by carboxyl, hydroxyl or carbonyl groups, and show an anionic nature in physiological environment

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Patients with MetSR demonstrated statistically significant improvement in depressive symptoms (DCD: SMD = 0.72, 95% CI: 1.41 to 0.03), while non-MetSR conditions showed no significant treatment effect (SMD = 0.57, 95% CI: 1.33 to 0.18)

10.1016/0165-6147(96)10005-5 189 RiazS