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The case is manifested by neuromyopathy-like symptoms including muscular hypotonia, psychomotor retardation, brain atrophy, developmental delay, and increased levels of methylmalonic acid and its metabolite (61)

Astrocytes take up glucose via GLUT1 and metabolize it via glycolysis, generating lactate through lactate dehydrogenase (LDH)

Liu T, Peng YF, Jia C, Yang BH, Tao X, Li J

So, focusing on PTP1B seems to be a positive approach to treat different abnormal metabolic conditions

Most clinical studies rely on microbiota analyses in gut microbiome research

Third, genetic rescue experiments targeting SREBP1 or ACC are necessary to establish the causal role of this pathway in mediating the GADD45 knockdown phenotype, but could not be performed due to current resource constraints