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Importantly, amino acid metabolism links to epigenetic regulation through production of metabolites like S-adenosylmethionine (SAM) and acetyl-CoA, influencing gene expression patterns that drive tumor progression [35,36,37,38,39]

DanaHChalbataniGMJalaliSAMirzaeiHRGruppSASuarezERet al

Samples were fixed in 4% paraformaldehyde, followed by sucrose dehydration, embedding, and transverse cryosectioning

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10.15171/jcs.2015.030 118 ShibataK.GrossC