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The HHQs exhibited moderate antischistosomal activity, with compound 88 (Figure 13) emerging as the most active (IC 50 = 40.0 M)

References Lee L, Gupta M, Sahasranaman S

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Therefore, we conclude that HMGA1-mediated regulation of HK2 represents the most plausible mechanism based on current evidence, while remaining open to the possibility that additional factors may contribute to this regulatory network