Disclosures: Jasmohan Bajaj: Bausch: Grant/Research Support, Sequana: Grant/Research Support, Cosmo: Grant/Research Support, Grifols: Grant/Research Support, Masoumeh Sikaroodi: Nothing to Disclose, Marcela Pea Rodrguez: Nothing to Disclose, Puneeta Tandon: Nothing to Disclose, Jennifer Lai: Nestle Nutrition Institute: Grant/Research Support, Novo Nordisk: Consultant, Genfit: Consultant, Boehringer Ingelheim: Advisor, Jacqueline Oleary: Grifols: Consultant, Cellion: Advisor, Mallinckrodt: Advisor, PharmaIn: Consultant, Genfit: Consultant, CVS: Stock - publicly traded company, Guadalupe Garcia-Tsao: Nothing to Disclose, Florence Wong: Mallinckrodt: Consultant, Mallinckrodt Pharmaceutical Inc: Grant/Research Support, River 2 Renal: Consultant, Sequana Medical: Consultant, sequana Medical: Grant/Research Support, Hugo Vargas: Sequana Medical: Consultant, Mallinckrodt: Consultant, Ocelot: Grant/Research Support, Arrowhead Phama: Grant/Research Support, Takeda: Grant/Research Support, Durect: Grant/Research Support, River2Renal: Grant/Research Support, Genfit: Grant/Research Support, Kezar Pharmaceuticals: Grant/Research Support, Scott Biggins: Nothing to Disclose, Patrick Kamath: Sequana: Advisor, NovoNordisk: Advisor, Brian Bush: Nothing to Disclose, K Rajender Reddy: Nothing to Disclose, Patrick Gillevet: Nothing to Disclose 1034 DIETARY INTERVENTION IMPROVES INTESTINAL PERMEABILITY AND REDUCES COLON FIBRO-INFLAMMATION IN THE GAN DIET-INDUCED OBESE AND BIOPSY-CONFIRMED MOUSE MODEL OF MASH Susanne Pors 1 Jacob Nhr-Meldgaard 1 Kristoffer Voldum-Clausen 1 Anitta Kinga Sarvari 1 Sakthi Jagadeesan 2 Kasper Almholt 3 Natalia Petersen 3 Charlotta Dornonville de la Cour 3 Sebastian Beck Jrgensen 3 Henrik Hansen 1 Michael Feigh 1 , 1 Gubra, 2 Artus Therapeutics, 3 Novo Nordisk Background: The gutliver axis is considered playing an important role in metabolic dysfunction-associated steatohepatitis (MASH)
Specifically, FMN and FAD act as cofactors for certain enzymes (flavoproteins) involved in electron transfer reactions (e.g., energy production reactions, metabolic conversion of essential micronutrients such as that of folate, vitamin B 6 , niacin), drug metabolism, toxin detoxifying, and electron scavenging pathways
Please ensure the selected product option is appropriate for your own laboratory environment, research documentation and institutional procedures before ordering
ab8580, Abcam), rabbit anti-H3K27 ac (1:1000
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Science 379 , eabp8964 (2023)
