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BCAAs The three BCAAs of valine, leucine, and isoleucine are catabolized by BCAA aminotransferase (BCAT) and branched-chain -ketoacid dehydrogenase (BCKD) enzymes into intermediates like acetyl-CoA and methylmalonay-CoA, which enter the TCA cycle [113, 150]

J Med Chem 56:521533

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Additionally, IL-6 and IL-23 can drive Th 17 differentiation, with IL-17 recruiting neutrophils that infiltrate thyroid tissue, causing direct damage to follicular epithelial cells (Stadhouders et al., 2018)

Firstly, a comprehensive understanding of the mechanisms underlying hormetic responses, especially within the complex context of whole foods and food matrices, is lacking

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