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According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects

Br J Nutr 1997;77:685702 [DOI] [PubMed] [Google Scholar] 34.Campbell WW, Crim MC, Dallal GE, Young VR, Evans WJ

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