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Numerous studies have emphasized the critical role of mitophagy in promoting the survival of cardiomyocytes during pre-ischemic stress in ischemic cardiomyopathy

This does not mean they are unsafe

Salehi B, Machin L, Monzote L et al (2020) Therapeutic potential of quercetin: new insights and perspectives for human health

If, for example, the uptake of an aroma substance becomes too high, its usual excretion pathway may be oversaturated, and alternative routes may be recruited

Apart from a few exceptions (e.g., vitamin D), the human body cannot synthesize vitamins on its own in sufficient amounts and must, therefore, ensure a steady supply through the diet

Once the intracellular pool of GSH is exhausted, NAPQI covalently combines with cellular proteins, which results in mitochondrial dysfunction and oxidative stress 5