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We also disagree with the applicant's interpretation of the pacemaker example

Sparaco M, Gaeta LM, Santorelli FM, Passarelli C, Tozzi G, Bertini E, Simonati A, Scaravilli F, Taroni F, Duyckaerts C, Feleppa M, Piemonte F: Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities

While short term implementation of ketogenic diets has shown potential in several neurodegenerative diseases for improving metabolic function and producing neuroprotective and anti-inflammatory intermediates [99], long-term implementation is limited by decreased patient adherence and occasional adverse cardiac, renal and cognitive events (particularly in pediatric patients) [100]

doi: 10.1016/S0899-9007(00)00413-5 42

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