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Duration and Requirements: The complete circuit (citadel + hike to Intipunku) can take between 3 to 4 hours, depending on the visitors pace

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1,2 Although the clinical diagnosis of PD relies on the appearance of motor manifestations, extensive neuropathological dissemination initiates decades earlier, posing a significant challenge for early diagnosis

Adv Drug Deliv Rev 64:640665 Kannan R, Kuhlenkamp JF, Ookhtens M, Kaplowitz N (1992) Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence