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While the second-order rate constants of PfGrx C88S and PfGrx C32S/C88S for GSSG are one order of magnitude higher than for bulky roGFP2(SSG), the rate constant for the glutathionylation of PfGrx C32S/C88S by GSSG is twice that with GSSCys (Table 1) 14

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In addition, tissue levels of malondialdehyde (MDA), a lipid peroxidation marker, were reduced in DMF treated SCD mice than control mice (Fig

Furthermore, when ROS exceeds a certain threshold, it leads to oxidative stress ( Mechanisms governing ferroptosis Ferroptosis, unlike apoptosis, autophagy, and cell necrosis, is a regulatory form of cell death that depends on iron and ROS