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Furthermore, extensive research has demonstrated that EVs can also carry antigens, toxins, and pro-inflammatory cytokines, potentially serving as drivers of inter-organ diseases 154,155,156

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Using an ERE-luciferase mouse, a reporter mouse that allows monitoring of ER transcriptional activity in a spatiotemporal manner, it was demonstrated that estrogen signaling is locally activated in keratinocytes in vitro (with 1 nM E2) and in vivo (with 10 nM E2)