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While the precise regulatory pathways continue to be studied, findings suggest that glutathione plays a foundational role in supporting biological processes related to cognitive resilience, metabolic balance, and long-term cellular health

Table 3 Systemic therapeutic potential (oncology, gastroenterology, endocrinology (diabetes), cardiology, and neurology (gut-brain) of probiotics: a multi-disciplinary synthesis of mechanistic pathways and clinical efficacy

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Acetylation of FOXO3 by p300/CBP and deaetylation by sirtuins (Sirt1, Sirt2 and Sirt3) also provide a fine-tuning regulatory mechanism of FOXO3 activity depending on the cellular context and types of stress stimuli 81 - 83

Scholpp, J., Schubert, J

Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease