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Studies have shown that 1-AT promotes the transcription of COL2A1, ACAN, and SOX9 genes while downregulating the expression of MMP13 and ADAMTS5 genes, providing a protective effect against joint inflammation and cartilage degradation (95)

doi: 10.1016/j.tibs.2003.12.004 149 CollingridgeGLPeineauSHowlandJGWangYT

Nancy Scanlan is Executive Director for the AHVM Foundation

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Zhou, Y., Wang, S., Li, Y., Yu, S

Furthermore, this effect is dose-dependent

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