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The outer layers of the grain (the bran and the aleurone layer, the outermost layer of the endosperm, remaining attached to the bran during milling) and the germ are rich in folate, and they are generally separated during milling from the starchy endosperm, which is ground into flour 304,305,306,307,308,309,310,311,312,313,314,315,316,317,318

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Th1 cells amplify macrophage activation through IFN- ( 3.3 Dendritic cells in DKD pathogenesis Dendritic cells (DCs), which originate from bone marrow precursors, are professional antigen-presenting cells that connect innate and adaptive immunity

Reduced BDNF availability may in turn limit TrkB phosphorylation and attenuate downstream PI3K/Akt and MAPK/ERK signaling (Numakawa and Kajihara, 2023)