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doi: 10.3389/fphar.2020.590855 Received 03 August 2020 Accepted 18 September 2020 Published 15 October 2020 Volume 11 - 2020 Edited by Efstratios Stratikos, National Centre of Scientific Research Demokritos, Greece Reviewed by Marcin Poreba, Wrocaw University of Science and Technology, Poland Akira Hattori, Kyoto University, Japan Updates Copyright 2020 Hallberg and Larhed

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In line with CNS inflammation, prolonged microglial activation has also been reported in the brains of mice latently-infected with HSV, as indicated by high MHC class-II expression levels in CD45 int CD11b + cells up to 30 days post-infection (Figure 3B