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Description

Cell Stem Cell 12 , 141142 (2013)

Phase II study of durvalumab (anti-PD-L1) and trametinib (MEKi) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC)

J.CarlsonD

It isolates Nrf2 frpm the cytoplasm, preventing Nrf2 from entering the nucleus, and exerts its transcriptional activity to coordinate the expression of cell-protective genes, thereby maintaining cellular homeostasis