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Data availability The inclusion and exclusion criteria data that support the findings of this study are available from ClinicalTrials.gov The synthesized raw data is also available upon request

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Identification of exosome-dependent ITalk-labeled secreted proteins Exosomes are membrane-enclosed vesicles naturally released by nearly all cell types, including macrophages, and serve as an important mechanism for unconventional protein secretion 40

Data are normalized by citrate synthase (CS) protein levels

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6555% solution B for 24 min