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The four paralog sets identified two proteins that we previously identified as IIS regulated in worms and flies: pantothenate kinase and glycerol-3-phosphate dehydrogenase

10.1016/j.mrgentox.2010.05.010 Mutat

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The propeptide of type I procollagen (PINP), which is cleaved by protease during bone formation and excreted as a metabolite, reflects the rate of COL-I synthesis and osteogenic activity