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( A ) Klver-Barrera Luxol fast blue staining (LFB) and 2, 3-cyclic nucleotide 3-phosphodiesterase (CNPase) immunostaining of myelin in serial brain coronal paraffin sections from representative vehicle- (left column), XPro1595- (middle column), and etanercept-treated (right column) naive mice (CPZ0) or cuprizone-fed (CPZ-fed) CPZ3, CPZ5, CPZ6+1, and CPZ6+4 mice ( n = 8 for vehicle-treated CPZ0, n = 4 for XPro1595-treated CPZ0, and n = 612 for all other time points)

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The primary effect will be loss of the metabolic rate enhancement, though tirzepatide's appetite suppression remains intact