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Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, Chalasani N, Dasarathy S, Diehl AM, Hameed B, Kowdley KV, McCullough A, Terrault N, Clark JM, Tonascia J, Brunt EM, Kleiner DE, Doo E (2015) Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

Using distilled water (9 ml), three samples of each QTLN formulation (1 ml) were diluted to assess the particle size and PDI in three replicates using dynamic light scattering (DLS, Malvern, Germany)

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In the context of hepatic IR associated with non-alcoholic fatty liver disease (NAFLD), this molecular pathway becomes dysregulated, leading to impaired suppression of hepatic gluconeogenesis