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The liver is responsible for breaking down hormones like estrogen

The spectrum of physiological intervention of zinc is as broad as it gets and includes gene expression and regulation, cell signalling, cell proliferation, apoptosis, DNA metabolism and structural stabilization of chromatin (like sperm chromatin and its decondensation as needed), immune responses, defensive action against oxidants and many other vital physiological processes for sustenance of body homeostasis (Costa et al., 2023) (Table 1)

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Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L et al (2004) Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

Immunofluorescence staining of brain tissue examined the expression of tumor necrotic factor-alpha (TNF-, pro-inflammatory cytokine), glial fibrillary acidic protein (GFAP, a marker of activated astrocytes), sequestosome 1 (p62, marker of autophagic activity), voltage-dependent anion channel 1 (VDAC1, marker of mitochondrial stress), and NADPH Oxidase 4 (NOX4, marker of mitochondrial stress)