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doi: 10.3390/cancers16081554 427 NurkolisFQhabibiFRYusufVMBulainSPradityaGNLailossaDGet al

At the NMJ, succinylcholine binds to and activates nicotinic acetylcholine (nACh) receptors on the skeletal muscle endplate

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45,51 An open to closed conformational change upon substrate binding was noted for CntL and involves the partially disordered interdomain linker in the CntLSAM binary complex becoming an ordered -helix in the CntLMTAxNA ternary complex

They also indicate that peripheral PRLM signatures may serve as clinically relevant biomarkers for assessing disease activity and guiding patient stratification