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A subset of SCLCs lacks expression of either ASCL1 or NEUROD1, and some of these double-negative tumors are highly dependent on lower or absent expression of INSM1 [24, 42]

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Rats treated with the drug, as compared to a control group, showed significant improvement after less than one week of treatment, which continued for the remainder of the drug application and, for an additional 12 weeks after withdrawal from the drug, indicating sustained neurological amelioration of stroke-induced cognitive deficits