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Safety pharmacology and tolerability in animals Across short courses, studies report no overt toxicity at efficacious exposures, with normal clinical chemistry and hematology panels under commonly used dosing schedules

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Rats were anesthetized with an intraperitoneal injection of a mixture of Ketamine (90 mg/kg) and Xylazine (10 mg/kg)

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(2013) ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density