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Experimental study demonstrates that LDN induces a phenotypic shift in BV-2 microglial cells, transitioning them from a pro-inflammatory(iNOS high CD206 low ) to a quiescent, anti-inflammatory M2 state (iNOS low CD206 high ) [150]

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TRICARE works for substance abuse treatment much like a traditional health insurance plan, but it is specifically designed to support military members, veterans, and their families with both addiction recovery and mental health care

While considerable efforts have been directed toward understanding the peripheral mechanisms of CIPN, emerging evidence indicates that CIPN-causing agents also induce changes in CNS neurons, leading to the development of central sensitization (Figure 2E)

The gastric cancer tumor microenvironment is shaped by coordinated immune evasion, where tumor cells recruit suppressive populations (TAMs, MDSCs, and Tregs) and dampen effector T-cell and NK-cell function through checkpoint signaling, soluble mediators, and metabolic inhibitory circuits such as adenosine (155159) ( Supplementary Table 1 )