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Collectively, these findings underscore the significant potential of iron chelators in the treatment of CNS diseases, highlighting their dual role in attenuating iron-mediated toxicity and providing neuroprotection via multiple signaling pathways

In addition, there is a higher susceptibility of Nrf2 -null mice to liver injury [42], while the semi-synthetic oleanane triterpenoid compounds that activate Nrf2 were shown to be hepatoprotective in different models of liver disease (nonalcoholic fatty liver disease, acetaminophen-induced liver injury, and immune-mediated hepatotoxicity) that have been tested [40, 43,44,45]

Results: We generated a representative human model of ALGS reproducing ductopenia in a controlled and reproducible experimental environment

The functional reprogramming of LCs by 1,25(OH)D is highly dependent on the integration of skin microenvironmental cues

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Our study has also shown that the effect of NAC on ASA treatment in GSH-depleted cells was selective in terms of recovery of GSH metabolism and oxidative stress in different cellular compartments and on mitochondrial functions and apoptosis