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In liver, increased GSH efflux and increased oxidative stress both contribute [153,156]

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Pycnogenol showed effects to stop further progression of retinopathy and ameliorate the eyesight of diabetics by stabilizing and sealing leaky capillaries of the retina, stopping further outflow of blood ( In an RDP study, Pycnogenol was shown to reduce capillary leaking in the eyes ( supplementation for two months, the ophthalmoscopy score significantly improved by 9% in the left eyes and by 17% in the right eyes compared to baseline, whereas there was no change observed in the placebo group