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With age-related declines in self-synthesis, glutathione levels start deteriorating around the age of 45 and drop more rapidly after 60 [5][6]

doi: 10.1016/j.drudis.2020.07.002 50 SmithC.CortesR.GomezL

Rosenbloom KR, Sloan CA, Malladi VS, et al

This results not just in dehydration, but an electrolyte imbalance

This review synthesizes evidence that probiotics mitigate UC through multiple synergistic mechanisms: competitive exclusion to rebalance the microbiota, upregulation of tight junction proteins to restore the intestinal barrier, and bidirectional immunomodulation to restrain excessive inflammation