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Recent findings It is now recognized that intestinal permeability reflects the combined effects of two distinct routes across tight junctions, which form selectively permeable seals between adjacent epithelial cells, and mucosal damage that leads to nonselective barrier loss

-Concomitant treatment of Neuromeal plus with digoxin or lithium preparations may raise the serum levels of digoxin and lithium which lead to digoxin and lithium toxcitiy

Ding D, Liu J, Dong K, Melnick AF, Latham KE, Chen C

Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface

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Third, consider your study's endpoint