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J., Axler, C

Am J Physiol (1998) 275(6):E10231030

Causal association of diet-derived circulating antioxidants with the risk of rheumatoid arthritis: a Mendelian randomization study

513 IRE1 activation enhances TLR-mediated pro-inflammatory cytokine production in macrophages and neutrophils, with its regulated IRE1-dependent decay (RIDD) activity stabilizing cytokine mRNA and sustaining a robust inflammatory response in the RA synovium

Cell Stem Cell 12, 152165

Too much vitamin E in the body, however, can result in a state of vitamin E toxicity with gastric distress and an increased risk of bleeding due to the anticoagulant properties of vitamin E (Herbert, 1994)