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To reduce the collinearity across variables and number of features used for cluster analysis while retaining the majority of variance, we normalized the variables by converting raw scores to z -scores and applied principal component analysis (PCA, 23

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An impairment in mitophagy was found to be associated with cardiomyopathy, probably due to an increased number of dysfunctional mitochondria in the heart (18)

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Mitochondria are the main source of aerobic energy in eukaryotes

BRCP/ABCG2 is reportedly responsible for multi-drug resistance due to pumping drugs out of cancer cells, and GST also contributes via the detoxification and deactivation of anticancer drugs (Arvalo et al., 2017[5]