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Hassannia et al., 2021), lysophosphatidylcholine acyltransferase 3 (LPCAT3) (Reed et al., 2022), and arachidonate 15-lipoxygenase (ALOX15) (Ma et al., 2022) are key enzymes that participate in the biosynthesis and reconstruction of PE, activate PUFA, and affect its transmembrane characteristics, playing a key role in activating ferroptotic lipid peroxidation (Chen L