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Microscopic examination of brain tissue reveals the pathological signature of CTEphosphorylated tau protein (p-tau) that builds up in neurons, astrocytes, and cell processes around small blood vessels of the cortex, typically at the depth of cortical sulci (Asken, 2017

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Osteopontin and CD44, markers of the HFSC niche, were also increased

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This model of MRP1, built long before the release of the Cryo-EM structure of human MRP1 40 , remains in adequacy with the published Cryo-EM structure, validating our choice of mutants