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Regardless of the cause, the diagnosis of B12 deficiency is complex and can present at all ages with a wide spectrum of symptoms

BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death

Additionally, we previously discovered that the transcriptional mediator complex contributes to antioxidant gene expression via a direct interaction between Nrf2 and a mediator subunit, MED16 (Figure 2) [31]

doi: 10.1007/s40265-019-01192-z 46 DuftonNHannonRBrancaleoneVDalliJPatelHBGrayMet al

This immediate source of glutathione is considered a first line defence against oxidative stress-induced damage 12

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