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CA IX is one of three exofacial CA isoforms, along with CA IV and CA XII, and has a unique position in this enzyme family due to its strong association with cancer, hypoxia-related expression pattern, acidic pKa optimum, and inclusion of an extra proteoglycan-like domain protruding from the globular catalytic domain of the enzyme, which is anchored in the plasma membrane via a single-pass transmembrane region and a short cytoplasmic tail [23,24,25]

Spermidine/spermine N1-acetyltransferase (SAT1) is a regulatory enzyme of the polyamine catabolism process (Pegg, 2008)

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Sangtanoo et al., 2024)

MET is very safe and has no side effects, and is completely sourced and manufactured in Japan under stringent quality control

The optimal level of consumption was found to be 7-10 servings a day of fruit and vegetables [86, 87]