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656 Moreover, the AAV2/8 vector can mediate the expression of the human ETHE1 gene in the liver of ethylmalonic encephalopathy mouse models, effectively clearing circulating hydrogen sulfide, correcting plasma thiosulfate levels, restoring sulfur dioxygenase activity, significantly improving disease phenotypes, and extending lifespanhighlighting its potential for future clinical applications in treating ethylmalonic encephalopathy

Taken together, it could be hypothesized that GH administration is an effective therapeutic option for weight loss and fat mass reduction in obese individuals

The discovery of apoE Christchurch and the beneficial effect of the hybrid apoE2 + Christchurch variant in AD mouse models represent major breakthroughs in the field and could accelerate the development of clinical trials to assess the efficacy of AAV-mediated apoE therapy in AD [236]

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The Culture-Insert 2 Well was removed to allow the formation of a gap between cells seeded in the two chambers