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Adaptation to acid stress provides cross-protection to heat stress (Ryu and Beuchat, 1998

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Chronic exposure to these factors leads to sustained immune cell activation, which in turn drives mitochondrial dysfunction and elevated ROS levels further amplifying immune activation and inflammatory signaling (Kaliszewska et al., 2021

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doi: 10.1016/j.drup.2022.100916 13 NieZChenMGaoYHuangDCaoHPengYet al

We should also note that the first test is often the "tip of the iceberg" - and often on subsequent testing the levels increase since excretion capacity has improved