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258,259 Under stress conditions, Trx is released into the extracellular space where it exerts a cytoprotective effect and cytokine-like activities

This helps researchers assess the compound's effects more clearly and observe any lasting changes after administration ceases

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p53 Because of its role in cell cycle arrest, senescence, and apoptosis, as well as for its interesting role in metabolism, oxidative responses, and ferroptosis, p53 has long been an important focus of research

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In autoimmune conditions, curcumin (1025 M) ameliorates disease severity by suppressing pathogenic Th1/Th17 responses while enhancing the activity of regulatory T cells (Tregs) ( + T-cell function and inactivating the AKT/mTORC1/STAT3/PD-L1 axis ( + T-cell differentiation into CD4 + CD25+FOXP3+ Tregs (Figure 2)