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Hum Exp Toxicol 30 , 17011709, (2011)

In summary: While promising, these results are from animal models

The samples were transferred to microcentrifuge tubes, vortex mixed, and allowed to extract on ice for 10 min

However, AMPK activation has far-reaching implications, impacting key pathological processes, such as inflammatory signaling, oxidative stress regulation, and cellular maintenance pathways [158], all of which are deeply implicated in the pathogenesis of neurodegenerative disorders

7.3 Overarching challenges and future directions Future research priorities include clarifying the context-dependent duality of IGF-1, delineating its protective versus pathogenic roles across disease stages and cell types, and mapping crosstalk with core PAH pathways such as BMPR2/TGF- signaling