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Gain- and loss-of-function studies revealed that patients with homozygous mutations in the YIPF5 gene develop neonatal/early-onset diabetes ( 5 Role of ER stress in the functionality of hPSC-derived pancreatic -cells Human embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), collectively termed human pluripotent stem cells (hPSC) are unique cells that have the ability to be differentiated virtually into any cell types in the body including pancreatic -cells due to their infinite self-renewal competency

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