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[50] [53] The extracellular ligand-binding pocket is closed by a flexible "lid," and the intracellular region includes a short helix (H8) stabilized by -stacking interactions, both of which contribute to the receptor's dynamic conformational landscape

Previous animal studies have clearly shown a dose-dependent satiety effect of bupropion following intraperitoneal injection (52)

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HUBERMAN: In order to find out the lethal dose of something, as you can imagine, unfortunately, the way these studies are done is they give animals more and more, that is higher and higher doses of a given compound, find out at what point about 50% of the population of those animals starts to die, and then that's the so-called LD50, or at least that's one crude way of describing it

A 5/16 inch needle is shorter than a 1/2 inch needle