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This review explores the biology of aging, the role of senescent cells in AD pathology, and various senotherapeutic approaches such as senolytics, dampening the SASP (senescence associated secretory phenotype), senescence pathway inhibition, vaccines, and prodrugs

IFN- is essential to inducing broad, nonspecific resistance against viral infection by regulating the expression of multiple antiviral genes

doi: 10.1097/MEG.0b013e328318ed19 54

Mitochondrial dysfunction is often observed in NAFLD patient livers, and our data showed hepatic expression of Ubc13 was significantly downregulated in livers of NAFLD patients analyzed by GeoMx and IHC, further suggesting the role of Ubc13 in mitochondrial functions in NAFLD

It is not just inflammation that is involved in the development of neurodegeneration, but also several factors that interact amongst themselves and that include mitochondrial damage, which is closely related to oxidative stress 8,9

SARS-CoV-2 promotes distinct mitochondrial subpopulations that lack cristae or the ability to produce ATP Recent advances in mitochondrial bioenergetics reveal that mitochondria dynamically respond to nutrient deficiency by forming distinct subpopulations that either specialize in the production of ATP or macromolecular precursors that support cellular growth [390]