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*Correspondence: Alejandro Gonzlez-Candia [email protected] This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In fact, it is the epigenome that has tremendously evolved since the appearance of the first multicellular organisms