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Type-2 radiosensitizers are mostly metal-based materials that can strongly absorb, scatter and reemit radiation energy, resulting in a local radiation dose increase when they are accumulated in tumors 15,16

In addition, Gln metabolism regulates the pentose phosphate pathway (PPP), one of the central carbon metabolic pathways splitting from glycolysis at glucose-6-phosphate (G6P) and producing ribose-5 phosphate (R5P), a precursor for ribonucleotide synthesis

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Glutathione reductase is essential for maintaining adequate levels of reduced glutathione, and its suppression limits the capacity of cells to neutralize reactive oxygen species, thereby amplifying oxidative stress